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Related Experiment Video

Updated: Apr 29, 2026

Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
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Stimuli-Responsive Oligolysine-PEG Coatings for Reductive-Triggered Decomplexation.

Hugo J Rodríguez-Franco1, Artem Kononenko1, Maartje M C Bastings1

  • 1Programmable Biomaterials Laboratory, Institute of Materials, Interfaculty Bioengineering Institute, School of Engineering, Ecole Polytechnique Fédérale Lausanne, Lausanne 1015, Switzerland.

ACS Polymers Au
|August 18, 2025
PubMed
Summary

Responsive DNA origami nanoparticles (DONs) were developed using cleavable oligolysine-PEG coatings. These coatings protect DONs in physiological conditions and release them in the cell

Keywords:
DNA origami nanoparticlesbiointerfacesreductive deprotectionstabilizing coatingsstimuli-responsive polymers

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Materials Science

Background:

  • DNA origami nanoparticles (DONs) show promise for biological applications but face challenges from nuclease activity and ionic conditions.
  • Oligolysine-PEG coatings stabilize DONs but are static, limiting dynamic interactions and functional cue availability.

Purpose of the Study:

  • To develop responsive oligolysine-PEG coatings for DNA origami nanoparticles (DONs).
  • To enable controlled release and functional recovery of DONs in specific cellular environments.

Main Methods:

  • Incorporation of labile disulfide bridges into oligolysine segments of PEG coatings.
  • Synthesis and characterization of oligolysine-PEG variants with varying peptide segmentation.
  • Evaluation of DON protection under physiological conditions and decomplexation in reductive environments.

Main Results:

  • Developed oligolysine-PEG coatings that protect DONs in physiological conditions.
  • Demonstrated efficient decomplexation of DONs in reductive cellular environments via disulfide bond cleavage.
  • Observed that the number and positioning of disulfide linkers influence DON functional recovery.

Conclusions:

  • Responsive oligolysine-PEG coatings can be designed for stabilized DONs.
  • This strategy enhances the biomedical applicability of DONs by enabling controlled release and functionalization.
  • Provides a foundation for advanced responsive nanomaterials in biological systems.