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Word Picture Verification Performance Reveals Auditory Comprehension Deficits in Primary Progressive Aphasia.

Samuel Suh1, Elizabeth DeLuque1, Catherine Kelly1

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Phipps 546, 600 N. Wolfe Street, Baltimore, Maryland, 21287, USA.

Journal of Neurolinguistics
|August 18, 2025
PubMed
Summary
This summary is machine-generated.

Spoken word/picture verification is more sensitive for detecting auditory comprehension deficits in primary progressive aphasia (PPA) than matching tasks. This method reveals semantic errors, aiding in distinguishing PPA subtypes and guiding anomia treatment.

Keywords:
auditory comprehensionphonologicprimary progressive aphasiasemantic

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Area of Science:

  • Neuroscience
  • Linguistics
  • Psychology

Background:

  • Word/picture verification effectively measures lexical-semantic abilities in post-stroke aphasia.
  • Auditory comprehension deficits in primary progressive aphasia (PPA) require further investigation.
  • Previous studies have not extensively explored word/picture verification in PPA.

Purpose of the Study:

  • To assess the sensitivity of spoken word/picture verification and matching tasks in identifying auditory comprehension deficits in PPA.
  • To analyze error patterns in PPA subtypes to understand semantic and phonological processing disruptions.
  • To compare the diagnostic utility of verification versus matching tasks for single-word auditory comprehension in PPA.

Main Methods:

  • Evaluated 108 individuals with PPA (logopenic, nonfluent agrammatic, semantic variants) using spoken word/picture verification and matching tasks.
  • Quantified the number of individuals identified as impaired by each task.
  • Categorized errors as semantic or phonologic to analyze processing deficits.

Main Results:

  • Spoken word/picture verification identified 47% of individuals as impaired, significantly more than the matching task (20%).
  • Errors in verification were predominantly semantic, particularly in logopenic and semantic PPA variants for both nouns and verbs.
  • Nonfluent agrammatic PPA showed semantic errors for nouns but not verbs.

Conclusions:

  • Spoken word/picture verification is a more sensitive tool for detecting single-word auditory comprehension deficits in PPA.
  • The semantic error patterns support a distributed model of semantic knowledge, indicating degradation of semantic representations in PPA.
  • Findings can help differentiate PPA subtypes and inform treatment strategies for anomia.