Related Experiment Video
Updated: May 3, 2026
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
Bibliometric analysis of pathological mechanisms in Alzheimer's disease: Applications based on mouse models
Jinjiang Li1,2, Zhaoxiong Lin1,2, Yufei Niu1
1First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Background:
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. Animal models play a key role in exploring its pathophysiological mechanisms.
Objective:
To analyze global research trends and knowledge structure in AD pathophysiological mechanisms based on animal models.
Methods:
Publications from 2014 to 2023 were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used for bibliometric analysis and data visualization.
Results:
A total of 2169 publications were identified, with a steady growth trend. The United States and China were the leading contributors, with Harvard University as a major collaborative hub. The Journal of Alzheimer's Disease published the most articles, while the Journal of Neuroscience had the highest co-citation frequency. Holtzman DM was a key author in the field. Nine keyword clusters were identified, including insulin resistance, amyloid beta, and oxidative stress. Emerging topics include synapse loss, gut microbiota, and NLRP3 inflammasome.
Conclusions:
This study provides a concise overview of global research on AD pathophysiological mechanisms in animal models, offering valuable insights for future research directions.
More Related Videos
10:46Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
Published on: May 3, 2017
10:02Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
Published on: May 28, 2017
