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Updated: Sep 11, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
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Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Mohamed Bilal Fares1, Omar Alijevic1, Stephanie Johne1

  • 1PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland.

Frontiers in Neuroscience
|August 18, 2025
PubMed

Keywords:
induced pluripotent stem cell (iPSC)neuroprotectionnicotinenicotinic acetylcholine receptors (nAChR)synucleinopathytransgenic mice

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Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
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