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Updated: Sep 11, 2025

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Relationship Between Cardio-Ankle Vascular Index (CAVI) and the Severity of Coronary Artery Lesions: A Case-Control

Le Van Dung1, Pham Nguyen Son2, Kieu Ly Thi Nguyen2

  • 1Department of Cardiology, Duc Giang General Hospital, Hanoi, Vietnam.

Vascular Health and Risk Management
|August 18, 2025
PubMed

Insights

Cardio-ankle vascular index (CAVI) is elevated in patients with chronic coronary artery disease (CAD) and effectively predicts its severity. Higher CAVI values correlate with more severe arterial stiffness and lesion complexity.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Arterial stiffness (AS) is a significant risk factor for cardiovascular diseases.
  • The cardio-ankle vascular index (CAVI) is a validated measure of arterial stiffness.

Purpose of the Study:

  • To investigate the utility of CAVI in predicting the severity of coronary artery disease (CAD).

Main Methods:

  • A case-control study involving 222 patients (160 with CAD, 62 controls) was conducted.
  • CAVI measurements were correlated with coronary artery lesion parameters including stenosis severity, number of diseased vessels, SYNTAX, and Gensini scores.

Main Results:

  • Patients with CAD exhibited significantly higher CAVI values compared to controls (9.21 ± 0.79 vs. 8.48 ± 0.62, p < 0.001).
  • CAVI (≥8.83) predicted chronic CAD with high accuracy (AUC = 0.796).
  • Elevated CAVI correlated with severe stenosis, multivessel disease, and higher SYNTAX and Gensini scores.

Conclusions:

  • CAVI is a valuable non-invasive biomarker for assessing arterial stiffness in patients with chronic CAD.
  • CAVI can effectively predict the presence and severity of coronary artery lesions.
Abstract

Keywords:
CADCAVIgensini scoressyntax scores

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