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  11. A Mobile Health Intervention In Caregivers Of Patients Undergoing Hematopoietic Cell Transplantation: A Randomized Controlled Trial To Examine Health-related Quality Of Life

A Mobile Health Intervention in Caregivers of Patients Undergoing Hematopoietic Cell Transplantation: A Randomized Controlled Trial to Examine Health-Related Quality of Life

Xiao Cao1, Michelle Rozwadowski1, Thomas M Braun2

  • 1Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.

BMC Digital Health
|August 18, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

The Roadmap mHealth app, designed for caregivers of cancer patients undergoing hematopoietic cell transplantation (HCT), did not significantly improve overall health-related quality of life. However, engagement with the app’s positive activities and chat forum notably enhanced caregiver mood.

Area of Science:

  • Digital Health Interventions
  • Oncology Supportive Care
  • Psychological Well-being

Background:

  • Caregivers are crucial for cancer patients, particularly those undergoing hematopoietic cell transplantation (HCT).
  • Traditional interventions to improve caregiver health-related quality of life (HRQOL) are resource-intensive.
  • The Roadmap mHealth app was developed to offer accessible, resilience-building support using positive psychology.

Purpose of the Study:

  • To evaluate the impact of the Roadmap mHealth app on caregiver HRQOL post-HCT.
  • To assess the feasibility and acceptability of using a mobile health app integrated with wearable devices in this population.

Main Methods:

  • A two-arm randomized controlled trial (RCT) involving 168 caregiver-dyads.
  • The intervention group used the Roadmap app with Fitbit integration for monitoring steps, sleep, and mood.
Keywords:
digital technologiesfamily caregivershealth-related quality of life (HRQOL)hematopoietic cell transplantation (HCT)

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  • PROMIS Global Health (physical and mental components) was measured at day-120 post-transplant; mood was tracked daily.

    • Main Results:

    • No significant differences in PROMIS Global Mental or Physical Health T-scores were observed between the intervention and control arms at day-120.
    • Caregivers using the app's positive activities and chat forum showed significant daily mood improvement over time.
    • The Roadmap app and Fitbit integration were rated as feasible and acceptable, with high Mobile App Rating Scale (MARS) scores.

    Conclusions:

    • While the primary HRQOL outcomes were not met, the app effectively improved daily mood among engaged users.
    • The study demonstrated the feasibility and acceptability of mHealth tools for caregiver support in HCT.
    • Findings suggest potential for targeted digital interventions to enhance psychological well-being in cancer caregivers.
    mobile health (mHealth)
    positive psychology