Related Experiment Video
Updated: Dec 30, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Global research status, hotspots and prospects of ferroptosis in glioma: a scientometric analysis
Jing Liu1, Zefeng He1, Zhansen An1
1Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Objective:
The primary approach to the treatment of glioma involves surgical intervention, which is often complemented by radiotherapy, chemotherapy, and electric field therapy. Nevertheless, the prognosis for many patients remains poor. There exists an urgent necessity to identify novel replacement therapy strategies. A great breakthrough has been made in the study of ferroptosis in gliomas. The objective of this study is to conduct a systematic review of the current research status of ferroptosis in gliomas utilizing bibliometric analysis.
Method:
Publications related to glioma and ferroptosis from 2014 to 2025 were retrieved from the Science Core Collection (WoSCC) database. A bibliometric analysis was conducted using VOSviewer, CiteSpace, and the R package.
Results:
A total of 440 publications from 38 countries, with China leading the way, were included in the analysis. The number of publications related to ferroptosis in gliomas has been steadily increasing each year. The primary research institutions contributing to this field include Central South University, Nanjing Medical University, Shandong University, and Southern Medical University. Frontiers in Oncology is the leading journal for ferroptosis research in gliomas, while Cell is the most frequently cited journal in this field. These publications were authored by 2,921 individuals. Among them, Lu Shan, Wang Xuanzhong, Chen Qianxue, Sun Qian, and Xu Yang contributed the highest number of articles, while Dixon, SJ was the most frequently co-cited author. Studying the mechanisms, targets, and immunotherapy of ferroptosis in gliomas are major topics in this field. "Oxidative stress," "gpx4," and "autophagy" are popular keywords in recent years. In addition, "chemotherapy" and "miRNA" are emerging topics in this field that are closely related to this study and warrant greater attention.
Conclusion:
This is the first bibliometric analysis of the relationship between ferroptosis and glioma conducted over the past 11 years. The analyzed studies elucidate the regulatory mechanisms of ferroptosis and its implications in cancer cells, identify emerging research hotspots and Frontiers in recent years, and offer valuable references for scholars investigating ferroptosis in glioma, thereby facilitating the exploration of novel alternative treatment options.
Insights
This bibliometric analysis reveals a growing research interest in ferroptosis as a potential treatment for glioma. Key topics include oxidative stress and autophagy, with chemotherapy and miRNA emerging as important areas for future study.
Area of Science:
- Oncology
- Biomedical Research
- Cancer Therapy
Background:
- Glioma treatment, including surgery, radiotherapy, and chemotherapy, has limited efficacy, necessitating novel therapeutic strategies.
- Ferroptosis, a form of regulated cell death, has emerged as a significant area of research in glioma.
- Understanding ferroptosis mechanisms is crucial for developing new glioma treatments.
Purpose of the Study:
- To systematically review and analyze the research status of ferroptosis in gliomas using bibliometric methods.
- To identify key trends, influential publications, and emerging topics in ferroptosis research related to glioma.
- To provide a comprehensive overview for researchers investigating ferroptosis as a therapeutic target for glioma.
Main Methods:
- Bibliometric analysis of publications on glioma and ferroptosis from 2014 to 2025.
- Data retrieval from the Science Core Collection (WoSCC) database.
- Utilized VOSviewer, CiteSpace, and R package for bibliometric analysis.
Main Results:
- Analysis of 440 publications from 38 countries, with a notable increase in annual publications.
- China leads in research output, with Central South University, Nanjing Medical University, Shandong University, and Southern Medical University as key institutions.
- Frontiers in Oncology and Cell are leading and most cited journals, respectively. Key research themes include mechanisms, targets, and immunotherapy, with "oxidative stress," "gpx4," and "autophagy" as prominent keywords. "Chemotherapy" and "miRNA" are emerging topics.
Conclusions:
- This study represents the first bibliometric analysis of ferroptosis in glioma over an 11-year period.
- The findings highlight the regulatory mechanisms and implications of ferroptosis in glioma cells.
- Identifies current research frontiers and provides valuable insights for developing novel therapeutic strategies for glioma.
