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Related Experiment Videos

Vindesine in plasma cell tumors.

L Salvagno, A Paccagnella, V Chiarion Sileni

    Tumori
    |December 31, 1985
    PubMed
    Summary

    This study evaluated vindesine (VDS) plus prednisone for plasma cell tumors. VDS showed potential activity in extramedullary plasmacytoma, even without prednisone.

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    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Plasma cell tumors, including multiple myeloma and extramedullary plasmacytoma (EMP), are often treated with chemotherapy.
    • Vindesine (VDS) is a vinca alkaloid with antineoplastic properties.
    • Prednisone is a corticosteroid frequently used in combination chemotherapy for plasma cell disorders.

    Purpose of the Study:

    • To assess the efficacy of vindesine (VDS) in combination with prednisone in patients with plasma cell tumors.
    • To evaluate the activity of VDS as a single agent in a specific subset of patients.

    Main Methods:

    • A total of 21 patients with plasma cell tumors received vindesine (3 mg/m2 IV on day 1) plus prednisone (100 mg PO on days 1-5), with cycles repeated every 8-12 days.
    • Three patients with gastric or duodenal ulcers did not receive prednisone.
    • Patients were heavily pretreated and resistant to prior M-2 regimen, with one exception.

    Main Results:

    • An overall objective response rate of 19% was observed (4 out of 21 patients).
    • Responses included 2 out of 15 patients (13%) with multiple myeloma and 2 out of 6 patients (33%) with extramedullary plasmacytoma (EMP).
    • Response durations varied from 2 to over 48 months. One untreated EMP patient achieved a complete remission with VDS alone.

    Conclusions:

    • The combination of vindesine and high-dose prednisone demonstrates activity in plasma cell tumors.
    • In multiple myeloma, responses may be primarily attributed to high-dose prednisone.
    • Vindesine appears to be an active agent in extramedullary plasmacytoma, potentially effective even as a single agent.

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