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Middle cerebral artery dissection: pathophysiology, diagnosis, and therapeutic options

Xiangpeng Yao1, Niao Yang2, Nao Yan3

  • 1The Second Clinical College of Wuhan University, Wuhan, Hubei, China.

Frontiers in Neurology
|August 18, 2025
PubMed

Insights

Middle cerebral artery dissection (MCAD) is a rare cerebrovascular condition causing stroke. This review details MCAD

Area of Science:

  • Neuroscience
  • Vascular Neurology
  • Radiology

Background:

  • Middle cerebral artery dissection (MCAD) is an uncommon yet serious cerebrovascular disorder.
  • It can result in ischemic stroke or hemorrhagic complications.
  • Increased detection rates are linked to advances in neuroimaging.

Purpose of the Study:

  • To provide a comprehensive review of Middle cerebral artery dissection (MCAD).
  • To cover MCAD's pathophysiology, imaging findings, and treatment options.
  • To synthesize current knowledge based on literature and guidelines.

Main Methods:

  • Systematic literature review using major databases (MEDLINE/PubMed, Cochrane, Web of Science, EMBASE).
  • Inclusion of the latest guidelines for intracranial artery diseases and stroke management.
  • Comprehensive synthesis of existing research.

Main Results:

  • Detailed review of MCAD pathophysiological mechanisms.
  • Description of characteristic imaging findings for diagnosis.
  • Outline of current and emerging treatment strategies.

Conclusions:

  • MCAD requires a thorough understanding of its complex mechanisms and presentations.
  • Accurate imaging is crucial for timely diagnosis and effective management.
  • Evidence-based treatment approaches are essential for improving patient outcomes.
Keywords:
imaging characteristicsmiddle cerebral artery dissectionpathophysiologyrisk factorstreatment

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