Related Experiment Video
Updated: Sep 11, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Beyond vision loss: the impact of glaucoma on the brain
Trinita Jude Hamilton1, Bettina E Kalisch1
1Department of Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
Abstract:
Glaucoma, a leading cause of irreversible blindness, is characterized by optic disc cupping and retinal ganglion cell (RGC) degeneration. Recent research highlights the broader impacts of glaucoma on the brain. Transsynaptic neural degeneration extends the RGC damage through the visual pathway and various other regions in the brain, leading to structural and functional changes. These neurodegenerative effects may result in cognitive impairment, affecting patients' daily activities and quality of life. Understanding the connection between glaucoma, the brain, and cognition is essential for intervention and developing comprehensive treatment strategies that address visual and neurological impairments, ultimately improving patient outcomes. This review examines the existing literature on the links between glaucoma pathology and the brain and explores the impacts on cognition and quality of life.
More Related Videos
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Photoreceptors and Visual Pathways
The Blood-brain Barrier
Anatomy of the Eyeball

