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Updated: Sep 11, 2025

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Published on: June 11, 2012
Pilot Study: Improving Glycemic Control Among Children and Adolescents With Obesity and Prediabetes With Real-Time
Zachary Z Mayer1, Timothy P Foster1,2, Xiaofei Chi1,3
1University of Florida College of Medicine, Gainesville, FL.
Objective:
To assess the feasibility and efficacy of a novel use of continuous glucose monitoring (CGM) in prediabetes to promote behavioral change and improve glycemia.
Research Design And Methods:
We conducted a single-arm prospective study in a pediatric obesity clinic to evaluate the feasibility and acceptability of wearing a CGM sensor in children aged 10-17 years with obesity (BMI ≥95th percentile for age) and prediabetes. Feasibility was determined through participant recruitment. We analyzed differences in A1C, glucose variability, BMI, and dietary intake at 12 weeks.
Results:
Of 22 participants recruited, 14 completed the study. Over 12 weeks, the mean BMI percentage of the 95th percentile decreased from 153.4 to 150.1% (P = 0.006), daily estimated carbohydrate consumption decreased by 41.4% (P = 0.009), and A1C decreased by 0.2% (P = 0.03).
Conclusion:
CGM in an adolescent population with prediabetes and obesity may be a helpful adjunct to therapy to improve A1C, support dietary changes, reduce the rate of weight gain, and attenuate diabetes risk.
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