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Long-term Function of Adults With Arthrogryposis
Shai Luria1,2, Doaa Qais1,2, Ido Volk1,2
1Faculty of Medicine, Hebrew University of Jerusalem.
Journal of Pediatric Orthopedics
|August 18, 2025
Summary
Adults with arthrogryposis have high quality of life despite significant physical limitations and pain. Spine surgery may improve upper-limb function, highlighting needs for better pain management and social rehabilitation.
Area of Science:
- Rehabilitation Medicine
- Orthopedics
- Quality of Life Studies
Background:
- Arthrogryposis multiplex congenita (AMC) presents diverse functional abilities influenced by disease severity and treatment.
- Understanding the relationship between physical impairments and long-term outcomes in adults with AMC is crucial for targeted interventions.
Purpose of the Study:
- To identify and describe associations between physical impairments and long-term functional outcomes in adults with arthrogryposis.
- To evaluate the quality of life and functional status of adult AMC patients.
Main Methods:
- Interviewed 42 adult AMC patients treated between 1988 and 2019.
- Assessed function and quality of life using PASIPD, Quick-DASH, and SF-36.
- Employed Fisher exact and Mann-Whitney tests for statistical comparisons.
Main Results:
- Adult AMC patients reported high education levels and quality of life, yet exhibited lower physical function and high rates of pain (back, hip, wrist).
- Upper-limb involvement was prevalent (>83%), with symptoms correlating to both upper and lower extremity function.
- Spine surgery was associated with improved upper-limb function.
Conclusions:
- A discrepancy exists between high reported quality of life/education and limited physical/upper-extremity function in adults with AMC.
- Pain management and social rehabilitation are key areas for improvement in this population.
- Upper-extremity function is linked to both upper and lower extremity joint symptoms and may benefit from spine surgery.
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