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Assessing Atopic Dermatitis severity in children from Georgia: the correlation of inflammatory blood markers to the
Janadi Karawita1, Faiza Yasmine Kabachi1, Aliya Modak1
1Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia.
Insights
Eosinophil Relative Count (ERC) and Eosinophil/Lymphocyte Ratio (ELR) show potential as blood markers for atopic dermatitis (AD) severity in children. Further research is needed to confirm their clinical utility in assessing AD activity.
Area of Science:
- Pediatric Dermatology
- Immunology
- Clinical Research
Background:
- Atopic dermatitis (AD) is a widespread chronic inflammatory skin condition in children.
- Systemic inflammation plays a crucial role in AD pathophysiology.
- Identifying reliable blood markers can aid in assessing AD severity and guiding treatment.
Purpose of the Study:
- To investigate the correlation between specific blood inflammatory markers and the Eczema Area and Severity Index (EASI) in pediatric patients with AD.
- To evaluate the potential of Eosinophil Relative Count (ERC), Neutrophil/Lymphocyte Ratio (NLR), Eosinophil/Lymphocyte Ratio (ELR), and Basophil/Lymphocyte Ratio (BLR) as objective indicators of AD severity.
Main Methods:
- A retrospective analysis of 22 pediatric patients diagnosed with AD.
- Blood parameters including ERC, NLR, ELR, and BLR were measured.
- These markers were statistically correlated with EASI scores.
Main Results:
- A significant positive correlation was found between EASI scores and both ERC (r=0.69, p<0.001) and ELR (r=0.71, p<0.001).
- No statistically significant correlation was observed between EASI scores and NLR (r=0.2059, p=0.3578) or BLR (r=0.1026, p=0.6494).
- Age was not found to be significantly associated with EASI scores (r=-0.0351, p=0.8767).
Conclusions:
- ERC and ELR demonstrate potential as objective blood biomarkers for evaluating the severity of atopic dermatitis in children.
- Larger-scale studies in pediatric populations are recommended to establish a definitive association for clinical application.
Background:
Atopic dermatitis (AD) is a chronic inflammatory skin condition prevalent among children worldwide. Systemic inflammation is a key factor in its pathophysiology. Correlating blood markers with Eczema Area and Severity Index (EASI) can reveal information about the severity and activity of the disorder, allowing for more focused treatment.
Methods:
A retrospective analysis was conducted on 22 patients aged 3 months to 18 years. Blood parameters, such as Eosinophil Relative Count (ERC), Neutrophil/Lymphocyte Ratio (NLR), Eosinophil/Lymphocyte Ratio (ELR), and Basophil/Lymphocyte Ratio (BLR), were correlated with the Eczema Area and Severity Index (EASI).
Results:
A strong positive correlation was observed between EASI scores and ERC (r = 0.69, p < 0.001) and with ELR (r = 0.71, p < 0.001). No statistical significance was seen between EASI scores and the NLR (r = 0.2059, p = 0.3578) and BLR (r = 0.1026, p = 0.6494). No significant association was found between age and EASI scores (r = -0.0351, p = 0.8767).
Conclusions:
ERC and ELR have the potential to serve as objective blood markers for assessing AD severity. However, more research in pediatric populations with a larger sample size is needed to establish a conclusive association for clinical practice.
