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Biocompatible Multifunctional Polymeric Material for Mineralized Tissue Adhesion.

Yan Luo1, Chenyang Zhang2, Sage Fulco1

  • 1Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Advanced Healthcare Materials
|August 18, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a new biocompatible dental adhesive resin that improves bonding to dentin. The novel resin system enhances mechanical properties and reduces cytotoxicity for stronger, longer-lasting dental restorations.

Keywords:
dentin adhesionmolecular dynamics simulationnanoindentationthiol‐ene polymerizationtriacrylate resin

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Area of Science:

  • Biomaterials Science
  • Dental Materials Science
  • Polymer Chemistry

Background:

  • Conventional dental adhesives can form inhomogeneous networks and release cytotoxic residual monomers.
  • Effective adhesion to dentin is crucial for the strength and longevity of dental composite restorations.

Purpose of the Study:

  • To develop a biocompatible, multifunctional thiol-ene resin system for improved dentin adhesion.
  • To enhance mechanical properties and reduce cytotoxicity in dental adhesive resins.

Main Methods:

  • Utilized molecular dynamics simulations to determine optimal monomer ratios.
  • Employed rheological, mechanical, shear bond, and nanoindentation tests.
  • Assessed in vitro biocompatibility with dental pulp cells and fibroblasts.

Main Results:

  • An optimal triacrylate:trithiol ratio of 2.5:1 was identified, yielding a storage modulus of ≈30 MPa.
  • The addition of bis[2-(methacryloyloxy)ethyl] phosphate (BMEP) significantly improved dentin adhesion to 10.8 MPa.
  • The developed resin demonstrated good biocompatibility with dental cells.

Conclusions:

  • The novel triacrylate-trithiol resin system offers enhanced bond strength and mechanical properties for dental applications.
  • Chemophysical bonding via BMEP and crosslinking contribute to improved performance and biocompatibility.
  • This resin system presents a promising alternative to conventional dental adhesives.