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Drug treatment analysis of infective endocarditis in children-a retrospective, single-centre study

Sanni Li1, Yan Meng1, Nan Zhang1

  • 1Children's Hospital of Hebei, Shijiazhuang, China.

Cardiology in the Young
|August 18, 2025
PubMed

Insights

This study on pediatric infective endocarditis found Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA), were common. Treatment involved specific antibiotics, but drug monitoring was infrequent.

Area of Science:

  • Pediatric Infectious Diseases
  • Cardiology
  • Antimicrobial Resistance

Background:

  • Infective endocarditis (IE) in children is a serious condition requiring prompt diagnosis and effective treatment.
  • Understanding causative pathogens and their antimicrobial susceptibility is crucial for guiding therapy.

Purpose of the Study:

  • To retrospectively analyze pediatric infective endocarditis cases.
  • To characterize causative pathogens, antimicrobial susceptibility, and treatment outcomes.
  • To inform clinical decision-making for pediatric IE management.

Main Methods:

  • Retrospective analysis of medical records from 2016-2023.
  • Identification and characterization of bacterial isolates.
  • Review of clinical data, treatment plans, and pharmaceutical monitoring.

Main Results:

  • Twelve pediatric IE cases identified; predominantly Gram-positive cocci.
  • Staphylococcus aureus, all methicillin-resistant Staphylococcus aureus (MRSA), was the most frequent pathogen (n=13).
  • Linezolid and vancomycin were primary antimicrobials; therapeutic drug monitoring was low (25% for vancomycin).

Conclusions:

  • Gram-positive cocci, particularly MRSA, dominate pediatric IE etiology.
  • Significant variation in drug resistance observed among streptococci species.
  • Low rates of therapeutic drug monitoring highlight a potential area for improvement in patient care.
Abstract

Keywords:
Endocarditischildrendrugs

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