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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
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Evaluating hematological and inflammatory biomarkers in tuberculosis management
Sanatkumar Bharamu Nyamagoud1, Princy Domnic Dsouza1, Sai Phalguna Prakash Chitralu1
1Department of Pharmacy Practice, KLE College of Pharmacy, Vidyanagar, Hubballi, Karnataka.
Summary
Hematological and inflammatory markers like hemoglobin and C-reactive protein show potential for monitoring tuberculosis (TB) patients. These cost-effective biomarkers can aid in TB diagnosis and treatment, especially where advanced tools are limited.
Area of Science:
- Clinical Medicine
- Biomarkers
- Infectious Diseases
Background:
- Tuberculosis (TB) poses a significant global health challenge, particularly in resource-limited areas.
- Accurate diagnosis and monitoring of TB progression and treatment response are critical but challenging.
- Hematological and inflammatory markers are potential indicators of disease activity.
Purpose of the Study:
- To evaluate the role of hematological and inflammatory biomarkers in TB patients.
- To assess the association of these biomarkers with disease status and demographic characteristics.
- To determine the utility of these markers for TB diagnosis, prognosis, and treatment monitoring.
Main Methods:
- Analysis of 80 TB patients.
- Measurement of hemoglobin (HB), serum amyloid A (SAA), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count.
- Pearson's correlation analysis to assess associations between biomarkers, disease status, and demographics.
Main Results:
- Elevated WBC, SAA, CRP, and ESR levels indicate active inflammation in TB patients.
- Decreased HB levels suggest anemia, common in chronic infections like TB.
- A significant negative correlation was found between HB and inflammatory markers.
- No significant associations were observed between biomarker levels and demographic parameters.
Conclusions:
- Hematological and inflammatory markers are valuable adjunctive tools for TB management, especially in resource-limited settings.
- These biomarkers can assist in TB diagnosis, prognosis, and treatment monitoring.
- Further research is needed to validate findings and explore their predictive role in treatment outcomes and disease severity.
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