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Updated: Sep 11, 2025

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
Published on: August 30, 2017
A carrier-free nano-photosensitizer for red light-activated NO release and combination therapy
Chaonan Li1, Huixuan Qi2, Jinjun Jia3
1School of Environment and Biological Engineering, Wuhan Technology and Business University, Hongshan District, Wuhan 430065, China.
Abstract:
In this work, multifunctional nanoparticles (A-PIB NPs) constructed by a nitric oxide (NO) donor, L-arginine, and a boron dipyrromethene derivative were used for red light-responsive and spatiotemporally-controllable NO release. A-PIB NPs could produce singlet oxygen and NO under 630 nm light irradiation, achieving controlled release of NO and being used for combination therapy of tumors.

