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Updated: Sep 11, 2025

Author Spotlight: Regulation and Dysregulation of ER-Mitochondria Contacts — Implications for Neurodegenerative Disease Pathogenesis
Published on: October 11, 2024
FOMO no more: NOMO and calmin extend mechanobiology to the ER
Julie Heffler1, Jan Lammerding1
1Weill Institute for Cell and Molecular Biology, Meinig School of Biomedical Engineering, Cornell University , Ithaca, NY, USA.
Abstract:
Research on cellular mechanotransduction has primarily focused on the cell surface and the cytoskeleton. In this issue, Naughton et al. (https://doi.org/10.1083/jcb.202505010) identify NOMO, an endoplasmic reticulum (ER)-resident protein, as a force-bearing element with crucial roles in muscle differentiation and function. In a complementary study, Merta et al. (https://doi.org/10.1016/j.celrep.2025.115502) demonstrate that calmin physically tethers ER tubules to actin filaments at focal adhesions, modulating their function.
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