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Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis

  • 0The Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
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August 18, 2025

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August 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Circulating tumor DNA (ctDNA) shows promise for colorectal cancer screening and treatment. Bibliometric analysis reveals key research trends like minimal residual disease and adjuvant chemotherapy, guiding future studies.

Area Of Science

  • Oncology
  • Molecular Diagnostics
  • Bibliometrics

Background

  • Circulating tumor DNA (ctDNA) is increasingly recognized for its role in colorectal cancer (CRC) management.
  • Significant research attention is focused on ctDNA's utility in screening, monitoring, and treatment strategies for CRC.

Purpose Of The Study

  • To conduct a bibliometric analysis of the research landscape concerning ctDNA and colorectal cancer.
  • To identify emerging trends, key research areas, and influential publications in the field.

Main Methods

  • Bibliometric analysis and visualization techniques were employed.
  • Data were collected from the Web of Science Core Collection and Scopus databases.
  • VOSviewer, CiteSpace, and R packages were utilized for analysis and visualization.

Main Results

  • A total of 1,730 publications were analyzed.
  • The United States and China were the most productive countries in terms of publications.
  • Trending topics included "minimal residual disease," "adjuvant chemotherapy," and "recurrence."

Conclusions

  • Bibliometric analysis reveals significant advancements and emerging trends in ctDNA applications for colorectal cancer.
  • Key research hotspots identified warrant further investigation by the scientific community.

Keywords:

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