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Related Experiment Videos

Acute poisoning by selenious acid.

A J Nantel, M Brown, P Dery

    Veterinary and Human Toxicology
    |December 1, 1985
    PubMed
    Summary

    A child’s ingestion of selenious acid caused severe poisoning, leading to organ damage and respiratory failure. This case highlights a potential link between acute selenium poisoning and Legionnaire’s disease.

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    Area of Science:

    • Toxicology
    • Pediatric Medicine
    • Infectious Diseases

    Background:

    • A 2-year-old child ingested 15 ml of Gun Blue solution containing selenious acid, nitric acid, and copper nitrate.
    • Immediate symptoms included vomiting blood-stained food with a garlic odor, progressing to coma and mechanical ventilation.

    Observation:

    • Esophago-gastroscopy revealed second-degree burns of the esophagus and stomach.
    • The child developed metabolic acidosis, leucocytosis, hyperglycemia, hemoconcentration, intestinal distension, cardiomyopathy, and multi-organ dysfunction.

    Findings:

    • Elevated plasma (285 µg/L) and urinary (28,459 µg/L) selenium concentrations confirmed acute selenium poisoning.
    • Despite initial improvement, the child developed acute respiratory distress, later requiring extracorporeal membrane oxygenation (ECMO).
    • Legionella dumofii was identified as the causative agent for the respiratory complications.

    Implications:

    • This case underscores the severe toxicity of selenious acid and its potential to cause multi-organ failure in children.
    • The development of Legionnaire's disease following acute selenium poisoning suggests a possible interaction or complication pathway.
    • Aggressive treatment was insufficient to prevent a fatal outcome, emphasizing the critical nature of this poisoning.

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