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Predicting median nerve depth from anthropometric features: A tool for safer invasive procedures
Sara Mogedano-Cruz1, Ángel González-de-la-Flor1, Cristina Rodríguez-Anadón1
1Department of Physiotherapy, Faculty of Medicine, Health and Sports, European University of Madrid, Villaviciosa de Odón, Madrid, Spain.
Plos One
|August 18, 2025
Summary
Mid-forearm circumference accurately predicts median nerve (MN) depth, aiding ultrasound-guided procedures. This anthropometric measure helps clinicians estimate needle depth, reducing potential nerve injury risks.
Area of Science:
- Anatomy
- Medical Imaging
- Biostatistics
Background:
- Accurate localization of the median nerve (MN) is critical for invasive procedures to prevent complications.
- This study focused on developing predictive models for MN depth using anthropometric features.
Purpose of the Study:
- To develop predictive models for median nerve depth based on anthropometric measurements.
- To identify key predictors of median nerve depth for improved clinical practice.
Main Methods:
- A cross-sectional observational study involving 53 healthy adults.
- Collected sociodemographic and anthropometric data (height, weight, BMI, forearm circumference).
- Utilized ultrasound to measure MN depth and employed hierarchical linear regression for analysis.
Main Results:
- Mid-forearm circumference was identified as a significant predictor of MN depth, explaining up to 95.2% of the variance.
- Men exhibited significantly greater height, weight, and forearm circumference than women.
- Models for nerve-to-artery distance showed limited predictive power (R² = 0.164).
Conclusions:
- Mid-forearm circumference is a robust and easily accessible predictor of median nerve depth.
- The developed models can assist clinicians in estimating optimal needle depth during ultrasound-guided interventions.
- This approach may contribute to a reduction in the incidence of nerve injury.

