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Updated: Sep 11, 2025

Scale-up Chemical Synthesis of Thermally-activated Delayed Fluorescence Emitters Based on the Dibenzothiophene-S,S-Dioxide Core
Published on: October 24, 2017
Site-Selective Electrochemical Intramolecular C(sp2)-H Selenylation for Dibenzoselenophene Synthesis
Indrajit Karmakar1, Yi-Xuan Jian1, Wan-Lin Cheng1
1Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan, R.O.C.
Abstract:
We report a robust and eco-conscious electrosynthetic protocol for efficiently constructing structurally diverse and biologically relevant dibenzoselenophenes. This transformation proceeds via electrochemical intramolecular C-H activation of bis(biaryl) diselenides, employing LiClO4 as a green electrolyte and tetrabutylammonium bromide as an additive, conducted in DMSO at 70 °C under a constant current of 10 mA using Pt/Pt electrodes. The newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free catalysis, short reaction times, high to excellent yields, broad substrate tolerance, scalability to gram-scale synthesis, operational simplicity, and environmental friendliness.
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