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Updated: Sep 11, 2025

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Metabolic syndrome-associated kidney disease in young adolescents and children
Rupesh Raina1, Jieji Hu2, Eugene Chan3
1Department of Nephrology, Akron Children's Hospital, Akron, Ohio, USA; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA.
Abstract:
The increasing prevalence of childhood obesity has led to a corresponding rise in metabolic syndrome (MetS), which is associated with a significant risk of kidney disease. There is a complex relationship between pediatric obesity and MetS, with metabolic derangements such as hypertension, dyslipidemia, and insulin resistance, contributing to kidney damage through multiple mechanisms. A focus on pediatric cardiovascular-kidney-metabolic health may lead to improvements in diagnosis, treatment, and management of MetS and kidney disease. This review aims to comprehensively evaluate MetS as a significant cause of kidney disease in children.
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