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Updated: Sep 11, 2025
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Deep Eutectic Solvents in Polymeric Drug Carriers: Insights into Release Behavior and Functional Integration.
Nining Nining1,2, Yoga Windhu Wardhana3, Taofik Rusdiana3
1Doctoral Program in Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Chemistryopen
|August 18, 2025
Summary
Deep eutectic solvents (DES) enhance polymer drug delivery systems by improving solubility and controlling release. These eco-friendly excipients offer a promising path toward safer, more efficient pharmaceutical technologies.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Green Chemistry
Background:
- Traditional drug delivery systems face challenges with drug solubility, bioavailability, and release control.
- Deep eutectic solvents (DES) offer an eco-friendly, tunable, and biocompatible alternative to conventional solvents.
- DES possess unique physicochemical properties beneficial for pharmaceutical applications.
Purpose of the Study:
- To review the formulation and performance of polymer-based drug delivery systems (DDS) incorporating DES.
- To highlight the role of DES as functional excipients in modifying drug release and enhancing solubility.
- To explore the potential of therapeutic DES (THEDES) and dual-function systems.
Main Methods:
- Comprehensive literature review of DES and polymeric carrier integration.
- Analysis of physicochemical effects of DES on polymer matrices.
- Examination of drug release mechanisms and kinetics in DES-polymer systems.
Main Results:
- DES incorporation significantly alters drug release kinetics and improves solubility in polymeric DDS.
- DES act as effective functional excipients, enhancing the performance of drug delivery platforms.
- Therapeutic DES (THEDES) demonstrate potential for dual drug delivery and therapeutic action.
Conclusions:
- DES-polymer systems represent a significant advancement in developing safer, high-efficiency pharmaceutical technologies.
- Future applications include stimuli-responsive systems, 3D-printed scaffolds, and personalized medicine.
- Further investigation into DES-polymer systems is crucial for advancing pharmaceutical innovation.
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