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Updated: Sep 11, 2025

Transuterine Fetal Tracheal Occlusion Model in Mice
Published on: February 5, 2021
Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia
Sabrina J Flohr1, Leny Mathew1, Holly L Hedrick1,2
1Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Pennsylvania, PA, USA.
Objective:
To describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH).
Study Design:
Retrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children's hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition.
Results:
Of 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid.
Conclusion:
Nearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.
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