Related Experiment Video
Updated: Sep 11, 2025
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
The relationship between healthy lifestyle score and incident cardiovascular disease: results from Isfahan Cohort
Shahnaz Amani Tirani1,2,3, Parisa Hajihashemi4, Motahare Bateni5
1Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Background:
Evidence on the combined impact of healthy lifestyle factors on cardiovascular disease (CVD) risk in the Iranian population is limited. This study aimed to examine the association between a healthy lifestyle score (HLS) and the incidence of CVD.
Methods:
This prospective cohort study, including 5419 adults aged over 35 years, was performed in the framework of the Isfahan Cohort Study (ICS) which is an ongoing study. The HLS (ranging from 0 (unhealthy) to 4 (most healthy)) was derived from four modifiable risk factors: never smoking, diet quality, physical activity, and body mass index (BMI). Investigated cardiovascular outcomes included myocardial infarction (MI), stroke, unstable angina (UA), and CVD mortality. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and assigned 95% confidence intervals (CI).
Results:
Over a median follow-up of 11.25 years, 785 CVD events occurred, including 159 MI, 164 stroke, 369 UA, and 172 CVD deaths. In the fully-adjusted model, participants with the highest HLS (3-4) had a significantly lower risk of stroke (HR: 0.51; 95% CI: 0.31-0.83; P trend = 0.019) and a tendency towards lower risk of CVD (HR: 0.78; 95% CI: 0.61-0.98; P trend = 0.053) compared to individuals with the lowest HLS (0-1). No significant association was found for MI, UA, or CVD mortality. Age- and sex-specific patterns were also noted for stroke and overall CVD.
Conclusion:
Our results suggest that a healthier lifestyle was linked to a reduced risk of stroke and showed a trend toward lower CVD risk among Iranian adults. These associations may vary by age and sex.
More Related Videos
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
10:21Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
Published on: September 22, 2023
Related Concept Videos
01:20Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
01:23Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
01:26Atherosclerosis III: Management
01:26Coronary Artery Disease IV: Preventive Measures
01:30Coronary Artery Disease I: Introduction
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...