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Postpartum colonic squamous cell carcinoma with a BRAFV600E mutation: a case report
Qin Wang1, Huai-Gen Zhang2, Wei-Rong Yao1
1Department of Oncology, Jiangxi Provincial Hospital (The First Affiliated Hospital to Nanchang Medicine College), Nanchang, 330000, Jiangxi Province, China.
Journal of Medical Case Reports
|August 18, 2025
Summary
Primary squamous cell carcinoma of the colon is rare, especially postpartum. This BRAFV600E-mutated case highlights poor prognosis and limited treatment options for this uncommon colon cancer.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Primary squamous cell carcinoma of the colon is an exceptionally rare malignancy.
- Its occurrence in the postpartum period is even rarer, with no established treatment guidelines.
- BRAFV600E mutations are found in 8-12% of metastatic colorectal cancer cases.
Purpose of the Study:
- To report a rare case of postpartum descending colon squamous cell carcinoma with BRAFV600E mutation.
- To discuss the challenges in managing this aggressive cancer.
- To emphasize the need for further research into colonic squamous cell carcinoma, especially with BRAFV600E mutations.
Main Methods:
- Case report of a 37-year-old woman diagnosed with postpartum descending colon squamous cell carcinoma.
- The tumor harbored the BRAFV600E mutation.
- Treatment involved radical resection, adjuvant chemotherapy, and targeted therapy, followed by clinical trial enrollment due to recurrence.
Main Results:
- The patient developed a new colon lesion 8 months post-treatment.
- Despite enrollment in a clinical trial, the patient experienced rapid disease progression.
- The patient died approximately 6 months after starting the clinical trial.
Conclusions:
- Colonic squamous cell carcinoma, particularly in postpartum women, is associated with advanced stage and poor prognosis.
- BRAFV600E-mutated colorectal cancer generally has a poor prognosis and limited response to current therapies.
- Increased focus and research are crucial for colonic squamous cell carcinoma, especially BRAFV600E-mutated variants.
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