A mixed methods evaluation of an antimicrobial prescribing clinical decision support system app

This study evaluated how the usability and accessibility of a digital antimicrobial prescribing app influences clinical decision-making. Using a convergent parallel mixed methods design, the study assessed app usage patterns with surveys and interviews to identify common barriers. Among 700 users at a tertiary hospital, 61 completed the survey (7.3% response rate), including 52 prescribers. Additionally, 20 prescribers participated in interviews. While 87% found the guidelines relevant, only 52% rated navigation as easy, and 34% reported slower decision-making compared to other clinical decision support systems (CDSS). App use peaked during morning rounds (8-11 AM). Key challenges included navigation inefficiencies (59%), technical barriers, limited onboarding, and concerns around clinical AI transparency. Interviews highlighted frustration with excessive steps and a desire for simpler guideline access. Findings highlight the need for user-friendly CDSS tools integrated into clinical workflows, and stress the importance of stakeholder co-design to improve medication safety.