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A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
Published on: August 30, 2019
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Acute lung injury: pathogenesis and treatment
Huanqi Liu1, Junli Dong1, Cailin Xu1
1College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, P. R. China.
Journal of Translational Medicine
|August 19, 2025
Summary
Acute lung injury (ALI) involves inflammation, cell death, and barrier damage. New nanomedicine approaches offer promising therapeutic strategies for this critical condition.
Area of Science:
- Pulmonology
- Immunology
- Nanomedicine
Background:
- Acute lung injury (ALI) is a severe condition with high mortality, often resulting in respiratory failure.
- Understanding ALI pathogenesis is crucial for developing effective treatments.
Purpose of the Study:
- To review the complex pathogenesis of ALI.
- To discuss current prevention and treatment strategies for ALI.
- To explore the potential of advanced nanomedicine in ALI therapeutics.
Main Methods:
- Literature review of ALI pathogenesis mechanisms.
- Analysis of current clinical practices in ALI management.
- Evaluation of recent advancements in nanomedicine for ALI treatment.
Main Results:
- ALI pathogenesis involves inflammatory cytokines, NLRP3 inflammasome activation, oxidative stress, apoptosis, mitochondrial dysfunction, and barrier breakdown.
- Current treatments include lung protective ventilation, fluid management, stem cell therapy, and drug therapy.
- Advanced nanomedicine presents novel therapeutic avenues for ALI.
Conclusions:
- The intricate mechanisms of ALI contribute to significant lung tissue damage.
- Existing treatments offer supportive care, but novel therapeutic strategies are needed.
- Nanomedicine holds significant promise for future effective ALI treatments.
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