Related Experiment Video
Updated: Jun 5, 2026
07:35
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
1.7K
Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics
Johanna Viana1, Cecilia Castro2, Víctor Leiva3
1Department of Nephrology, Unidade de Saúde Local de Braga, Braga, Portugal.
Medical Gas Research
|August 19, 2025
Summary
Molecular hydrogen (H2) shows promise for kidney protection, reducing damage in acute kidney injury and chronic kidney disease. Further clinical trials are needed to confirm its benefits in nephrology.
Area of Science:
- Nephrology
- Biomedical Science
- Molecular Biology
Background:
- Acute kidney injury (AKI) and chronic kidney disease (CKD) present significant global health challenges.
- Molecular hydrogen (H2) exhibits potential therapeutic properties, including antioxidant, anti-inflammatory, and antiapoptotic effects.
- Existing research on H2-based renal interventions requires comprehensive review and analysis.
Purpose of the Study:
- To review and analyze the existing evidence on H2-based renal interventions.
- To examine the therapeutic mechanisms of H2 in kidney disease models.
- To identify bibliometric trends and research gaps in H2 nephroprotection studies.
Main Methods:
- A scoping review was conducted following PRISMA-ScR guidelines.
- Quantitative bibliometric analysis was integrated with qualitative thematic synthesis.
- Data were sourced from Scopus and Web of Science, identifying 69 relevant publications.
Main Results:
- H2 demonstrated consistent renoprotective effects, mitigating apoptosis, fibrosis, inflammation, and oxidative stress.
- Studies primarily originated from Asia (China, Japan), with research activity peaking in 2019 and 2024.
- Limited international collaboration was observed, alongside identified research gaps.
Conclusions:
- Hydrogen therapy holds significant promise for renoprotection in both AKI and CKD.
- Further robust clinical trials and standardized methodologies are essential for clinical adoption.
- H2 represents a potential novel therapeutic strategy in nephrology practice.
Keywords:
PRISMAScopus databaseWeb of Science databaseacute kidney injurybibliometric analysischronic kidney diseasehydrogen-rich salinehydrogen-rich waterinflammationnephrotoxicityrenal protectionMore Related Videos
11:02Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
644
10:31Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
279
Related Concept Videos
01:25Aquaporins
Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
01:24Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...