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Updated: Sep 11, 2025

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
Oncogenic Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus on Cell Metabolism and Cell Transformation
Quanyuan Wan1, Andrew J Tucker1, Jun Zhao1
1Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, Florida, USA.
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV) is a human double-stranded DNA virus that is responsible for the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD), and KSHV inflammatory cytokine syndrome (KICS). KSHV infection manipulates distinct cellular proteins and signaling pathways, resulting in immune escape, cell death inhibition, infinite cell growth, and cancer formation. Current treatments for KSHV-associated cancers are limited to conventional strategies targeting nonviral cancers which encounter limited efficacy and drug resistance. Understanding the molecular and cellular mechanisms underlying KSHV tumorigenesis is essential for the development of effective prevention and targeted therapeutics. In this review, we summarize recent studies and provide an updated understanding of the mechanisms employed by KSHV for metabolic reprogramming, cell immortalization, cell proliferation, and cell transition.
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