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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Published on: May 3, 2019

Trauma Revealing a Tumour: A Case Report.

Allan Zhou¹, Claire Liegeois¹, Suraya Zainal Abidin²

¹Emergency Medicine, Sengkang General Hospital, Singapore, SGP.

|August 19, 2025

Summary

A fall revealed a giant-cell tumour of bone (GCTB) in a young man

Area of Science:

Orthopedic Surgery
Oncology
Radiology

Background:

Giant-cell tumour of bone (GCTB) is a primary bone tumour typically occurring in skeletally mature individuals.
GCTB commonly affects the epiphysis of long bones, particularly around the knee.

Observation:

A 25-year-old male presented with acute left knee pain and swelling after a fall, with a history of several months of left knee pain.
Physical examination revealed a swollen left knee with limited range of motion.
Radiographs showed a lytic lesion on the left lateral femoral condyle.

Findings:

Computed tomography (CT) and magnetic resonance imaging (MRI) were performed.
Open biopsy and immunohistochemical staining confirmed the diagnosis of GCTB, with tumour cells positive for H3G34W.

Keywords:

bone neoplasms case report diagnostic imaging giant-cell tumour of bone pathological fractures

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The patient underwent surgical treatment including curettage, bone grafting, and internal fixation of the left distal femur.

Implications:

This case underscores that trauma can be the initial presentation of an undiagnosed bone tumour.
Clinicians should maintain a high index of suspicion for bone tumours in patients presenting with persistent or acute joint pain, especially after injury.
Early diagnosis and appropriate management of GCTB are crucial for optimal patient outcomes.