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Trauma Revealing a Tumour: A Case Report
Allan Zhou1, Claire Liegeois1, Suraya Zainal Abidin2
1Emergency Medicine, Sengkang General Hospital, Singapore, SGP.
Cureus
|August 19, 2025
Summary
A fall revealed a giant-cell tumour of bone (GCTB) in a young man
Area of Science:
- Orthopedic Surgery
- Oncology
- Radiology
Background:
- Giant-cell tumour of bone (GCTB) is a primary bone tumour typically occurring in skeletally mature individuals.
- GCTB commonly affects the epiphysis of long bones, particularly around the knee.
Observation:
- A 25-year-old male presented with acute left knee pain and swelling after a fall, with a history of several months of left knee pain.
- Physical examination revealed a swollen left knee with limited range of motion.
- Radiographs showed a lytic lesion on the left lateral femoral condyle.
Findings:
- Computed tomography (CT) and magnetic resonance imaging (MRI) were performed.
- Open biopsy and immunohistochemical staining confirmed the diagnosis of GCTB, with tumour cells positive for H3G34W.
- The patient underwent surgical treatment including curettage, bone grafting, and internal fixation of the left distal femur.
Implications:
- This case underscores that trauma can be the initial presentation of an undiagnosed bone tumour.
- Clinicians should maintain a high index of suspicion for bone tumours in patients presenting with persistent or acute joint pain, especially after injury.
- Early diagnosis and appropriate management of GCTB are crucial for optimal patient outcomes.
