Grinspan Syndrome Associated With Pemphigus Vulgaris Induced by COVID-19 Vaccination

Grinspan syndrome (GS) is characterized by the association of diabetes mellitus, hypertension, and lichen planus. It remains enigmatic to determine whether this represents a distinct pathology or if it is a lichenoid reaction secondary to the use of medications for treating hypertension and diabetes. Oral lichen planus (OLP) is a common mucocutaneous disease that can affect the skin, mucous membranes, or both. An association with pemphigus vulgaris remains exceptional. We describe a rare case of GS associated with pemphigus vulgaris induced by COVID-19 vaccination. An 80-year-old female with type 2 diabetes mellitus and vascular hypertension was admitted to our department for bullous dermatosis.