Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

495
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
495
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.2K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.2K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of a supervised outpatient residence to support ambulatory hematopoietic stem cell transplantation: experience from Puebla, México.

Bone marrow transplantation·2026
Same author

Predicting the response to hematopoietic stem cell transplantation in persons with multiple sclerosis: the significance of an early positive response.

Bone marrow transplantation·2025
Same author

The Number of CD34 Cells Employed in Autologous Hematopoietic Stem Cell Transplantation for Persons With Multiple Sclerosis Is Not Related to the Neurological Outcome of the Procedure.

Clinical transplantation·2025
Same author

Results of the Latin American Bone Marrow Transplantation Society (LABMT) activity survey 2019-2022: the impact of the COVID-19 pandemic and the increase in related haploidentical donors.

Bone marrow transplantation·2025
Same author

Early morbimortality in autologous hematopoietic cell transplantation performed on outpatient basis in patients with autoimmune diseases: experience in 1700 patients.

Bone marrow transplantation·2025
Same author

Low iron transferrin saturation might be beneficial in the outcome of autologous transplant in multiple sclerosis.

Scandinavian journal of immunology·2025

Related Experiment Video

Updated: Sep 11, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

535

aHSCT in multiple sclerosis.

Guillermo José Ruiz-Argüelles1,2

  • 1Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico.

British Journal of Haematology
|August 19, 2025
PubMed
Summary

Autologous haematopoietic stem cell transplantation (aHSCT) shows promise for multiple sclerosis (MS) treatment across all forms of the disease. This powerful therapy offers a potentially safer, more affordable alternative to novel MS drugs.

Keywords:
aHSCTmultiple sclerosistreatment

More Related Videos

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.3K
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.9K

Related Experiment Videos

Last Updated: Sep 11, 2025

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

535
Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

1.3K
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

9.9K

Area of Science:

  • Hematology
  • Neurology
  • Immunology

Background:

  • Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Current treatments for MS have limitations in efficacy and safety.
  • Autologous haematopoietic stem cell transplantation (aHSCT) is an emerging therapeutic option.

Purpose of the Study:

  • To analyze the United Kingdom's experience with aHSCT in multiple sclerosis.
  • To evaluate the effectiveness and outcomes of aHSCT across different MS subtypes.
  • To compare aHSCT with existing and novel therapeutic approaches for MS.

Main Methods:

  • Retrospective analysis of 364 patients with multiple sclerosis (MS) who underwent aHSCT.
  • Data collected from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT).
  • Assessment of treatment response across relapsing-remitting and other forms of MS.

Main Results:

  • Positive responses to aHSCT were observed in all types of multiple sclerosis.
  • Response rates were superior in relapsing-remitting forms of MS.
  • aHSCT demonstrated encouraging outcomes, supporting its role in MS management.

Conclusions:

  • Autologous haematopoietic stem cell transplantation (aHSCT) is a powerful treatment for multiple sclerosis (MS).
  • aHSCT appears more effective, safer, and affordable compared to many novel MS drugs.
  • Patient and family advocacy highlights aHSCT as a significant therapeutic advancement.