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Updated: Sep 11, 2025
Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
Published on: May 31, 2024
Advances in the Study of Pyroptosis in Dermatological Disorders
Shenghao Xue1, Yumeng Lin2, Lusheng Liu3
1School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Abstract:
Pyroptosis is a proinflammatory procedural cell die-off characterised by the forming of membrane pores that are mediated by a series of aerogelin proteins. Pyroptosis occurs by caspase-1 dependent typical signalling pathways, caspase-4/5/11 dependent atypical signalling pathways, and other signalling pathways (GSDME, GSDMD, GSDMA, GSDMB and GSDMC mediated signalling pathways). Pyroptosis may assist in the elimination of the pathogen as a type of mechanism of host defence, but pyroptosis-induced inflammation can lead to dysfunction and organ damage, exacerbating the pathology of the disease. Several existing researches have suggested that pyroptosis is implicated in the etiopathogenesis of a majority of dermatologic disorders, including systemic lupus erythematosus (SLE), psoriasis (PA), atopic dermatitis (AD), systemic sclerosis (SSc), vitiligo and chronic spontaneous urticaria (CSU). In this review, we examine the available literature, focusing on the mechanistic aspects of pyroptosis and the involvement of pyroptosis in the six dermatologic disorders mentioned above, to aid in further research in the future.
Insights
Pyroptosis, a programmed cell death, involves pore formation and inflammation. This review explores its role in skin diseases like psoriasis and lupus, aiding future research.
Area of Science:
- Immunology
- Cell Biology
- Dermatology
Background:
- Pyroptosis is a pro-inflammatory programmed cell death characterized by membrane pore formation.
- It involves caspase-dependent and GSDM-mediated signaling pathways.
- While a host defense mechanism, pyroptosis-induced inflammation can cause organ damage.
Purpose of the Study:
- To review the mechanistic aspects of pyroptosis.
- To examine the involvement of pyroptosis in six specific dermatologic disorders.
- To provide insights for future research in the field.
Main Methods:
- Literature review of existing research on pyroptosis.
- Focus on mechanistic pathways of pyroptosis.
- Analysis of pyroptosis's role in systemic lupus erythematosus, psoriasis, atopic dermatitis, systemic sclerosis, vitiligo, and chronic spontaneous urticaria.
Main Results:
- Pyroptosis plays a significant role in the pathogenesis of various skin conditions.
- Specific signaling pathways and GSDM proteins are implicated.
- Dysregulated pyroptosis contributes to disease exacerbation.
Conclusions:
- Pyroptosis is a key factor in the development and progression of several dermatologic disorders.
- Understanding pyroptosis mechanisms is crucial for developing targeted therapies.
- Further investigation is warranted to fully elucidate pyroptosis's role in dermatology.
