Related Experiment Video
Updated: Sep 11, 2025

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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
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Spatiotemporal Flt3L delivery via photoactivation enhances tumor-selective immunotherapy
Shiyao Yin1, Qian Liu2, Biao Liu2
1College of Pharmaceutical Sciences and Department of otolaryngology, Children's Hospital, Suzhou Medical College, Soochow University, Suzhou 215123, China. fml4747@sina.com.
Abstract:
We developed photoactivatable Flt3L-loaded EVs that generate localized photodynamic effects to eliminate tumor fibroblasts, degrade extracellular matrix, and recruit immune cells. This naturally derived system enables precise spatiotemporal control of immunotherapy while maintaining tumor specificity and safety.

