Related Experiment Video For HRAS
Updated: Sep 11, 2025

Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium
Published on: February 21, 2025
Primary Pulmonary Epithelial-Myoepithelial Carcinoma With Prominent Reactive Pneumocytes: Clinicopathological
Asuka Okada1, Sae Hato1,2, Motohiro Nishimura3
1Department of Respiratory Medicine, Saiseikai Suita Hospital, Osaka, Japan.
Abstract:
Primary salivary gland-type tumors may rarely be accompanied by hyperplastic alveolar cells, a pattern referred to as pneumocytic adenomyoepithelioma (PAM). Most previously reported cases have relied solely on immunohistochemical findings. In this report, we present a case involving three distinct types of epithelial cell components, identified through dual immunohistochemical staining for p40/TTF-1, in addition to the detection of HRAS mutation using next-generation sequencing. The female patient, in her 70s, underwent left lower lobectomy after a chest CT scan revealed a 20 mm solid mass in the left lower lobe. The final histopathological diagnosis was a primary pulmonary epithelial-myoepithelial carcinoma (EMEC). This paper presents a case of a primary pulmonary EMEC exhibiting so-called PAM morphology and includes a brief review of the literature.
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