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Patient and First-Degree Relatives Perceptions About Prediction and Prevention of Inflammatory Bowel Disease-A Multinational Survey

  • 0Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal.
United European Gastroenterology Journal +

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August 19, 2025

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August 19, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Most individuals at risk of inflammatory bowel disease (IBD) are willing to undergo predictive testing and preventive interventions. Acceptance of minimally invasive tests and lifestyle changes is high, with some openness to medications.

Area Of Science

  • Gastroenterology and Immunology
  • Predictive Medicine
  • Public Health

Background

  • Identifying biomarkers for predicting inflammatory bowel disease (IBD) onset is advancing.
  • Little is known about the willingness of at-risk individuals for predictive testing and preventive interventions.

Purpose Of The Study

  • Assess acceptance of predictive tests and preventive interventions among individuals at risk of IBD.
  • Identify factors influencing decisions regarding IBD prediction and prevention.

Main Methods

  • An anonymized electronic survey was distributed to parents of children at risk of IBD and first-degree relatives (FDRs) of IBD patients.
  • The survey assessed acceptance of predictive tests, preventive interventions, and influencing variables.

Main Results

  • 85% of 1327 participants were willing to undergo predictive testing, preferring blood, stool, or saliva tests.
  • 98% accepted preventive interventions, favoring dietary changes, exercise, and probiotics.
  • Acceptance of immunosuppressive treatments varied based on efficacy, difficulty, and risks.

Conclusions

  • Most respondents prefer minimally invasive predictive tests and non-pharmacological preventive measures.
  • Over one-third would consider immunosuppressive medications to prevent IBD onset.
  • Disease knowledge and quality-of-life perceptions significantly influence preferences for IBD prediction and prevention strategies.

Keywords:

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