Related Experiment Video

Updated: Sep 11, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

4.8K

A strategic approach to regulating new antimicrobials

Shilpi Malhotra1, Nitin Bansal1, V Ramasubramanian2

  • 1Division of Descriptive Research, Indian Council of Medical Research, New Delhi, India.

Journal of Global Health
|August 19, 2025
PubMed

Insights

Antimicrobial resistance (AMR) in India is rising, threatening critical antibiotics. A new framework is proposed to preserve new drugs by restricting access and mandating surveillance.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant threat to healthcare in India, with increasing resistance to critical and last-resort antibiotics.
  • Rising resistance limits treatment options for drug-resistant infections, necessitating urgent strategies for antimicrobial preservation.

Purpose of the Study:

  • To propose a regulatory and access framework to preserve and extend the longevity of new antimicrobials in India.
  • To address the challenges in enforcing existing regulatory initiatives and inform future national-level strategies.

Main Methods:

  • Review of emerging data on antimicrobial resistance trends in India.
  • Analysis of historical patterns of antimicrobial resistance development.
  • Examination of stakeholder perspectives on policy measures for responsible antimicrobial introduction.

Main Results:

  • Resistance to last-resort antibiotics is increasing, limiting therapeutic options.
  • Challenges exist in enforcing regulatory initiatives like Schedule H1 restrictions.
  • A strategic national-level approach is needed for introducing new antimicrobials.

Conclusions:

  • A proposed framework recommends restricting new antimicrobial access to hospitals with established antimicrobial stewardship and infection control programs.
  • Mandatory antimicrobial resistance surveillance reporting is a key recommendation.
  • Stakeholder engagement is crucial for developing effective policies for responsible antimicrobial introduction to combat rising AMR.

More Related Videos

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.2K
Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.0K

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
201
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.8K
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
241
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
92
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
482
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
156