Related Experiment Video
Updated: Sep 11, 2025
Techniques for Processing Eyes Implanted With a Retinal Prosthesis for Localized Histopathological Analysis
Published on: August 2, 2013
Myelination of the retinal nerve fibre layer: A case report
Gioia Riboni-Verri1, Riddhima Gautam2, Benson Chen3
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Cambridge Clinical Vision Laboratory, University of Cambridge, Cambridge, UK.
Background:
Aberrant myelination of the retinal nerve fibre layer (RNFL) can follow lamina cribrosa damage. Such cases may provide insight into how increased myelin affects the visual evoked potential (VEP), a key outcome in remyelination trials.
Objective:
We present the case of a myelinated RNFL in a patient with relapsing-remitting multiple sclerosis (RRMS) with accompanying electrophysiology.
Methods:
Visual assessments used a VisionSearch Plus, Heidelberg Spectralis optical coherence tomography, and Topcon fundus camera.
Results:
Full-field visual evoked potential (FF-VEP) peak time latency was abnormally short, 90 ms.
Conclusion:
This is the first known case report of a myelinated RNFL with electrophysiology, which supports the assertion that reductions in VEP latency correlate with myelination.
