[Angiospasm and dihydroergotamine--dangers in thromboprevention]

The advantages of perioperative low dose heparinization as well known. Angiospastic reactions of Heparin-DHE have been described. In some cases additional factors such as interruption of blood flow and application of sympathicomimetics, are supposed to be decisive for the course. In cases where the application of sympathicomimetics might be necessary, perioperative treatment with DHE should therefore be avoided. Consequent observation of the peripheric blood flow is required in traumatized patients. In addition to other vasodilating agents the intraarterial application of Prostaglandin E1 is of advantage in case of angiospastic reactions.