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Organochlorine Pesticide Residues in Children with Hematological Disorders

Rachit Khandelwal1, Sumaira Khalil1, Vipin Tyagi2

  • 1Department of Pediatrics, University College of Medical Sciences and GTB Hospital, New Delhi, Delhi, India.

Indian Pediatrics
|August 19, 2025
PubMed

Insights

Children with hematological disorders (HDs) have higher organochlorine pesticide (OCP) residues in their blood and bone marrow. Malignant HDs showed higher OCP levels than non-malignant HDs, indicating a potential environmental link.

Area of Science:

  • Environmental Health
  • Pediatric Hematology
  • Toxicology

Background:

  • Organochlorine pesticides (OCPs) are persistent environmental pollutants.
  • Exposure to OCPs has been linked to various health issues.
  • Limited data exists on OCP levels in children with hematological disorders (HDs).

Purpose of the Study:

  • To compare OCP residue levels in sera and bone marrow of children with malignant and non-malignant HDs.
  • To compare OCP levels in these children with healthy controls.

Main Methods:

  • A case-control study involving children aged 12 years or younger.
  • Included children with malignant HDs, non-malignant HDs, and healthy controls.
  • OCPs were quantified in serum and bone marrow aspirates using gas-liquid chromatography/electron capture detection.

Main Results:

  • Serum OCP levels were significantly higher in children with malignant and non-malignant HDs compared to controls.
  • Malignant HDs exhibited higher serum OCP levels than non-malignant HDs.
  • Specific OCPs like hexachlorocyclohexane and endosulfan showed differential levels between HD groups and in bone marrow.

Conclusions:

  • Children with HDs have significantly elevated OCP residues in their sera compared to healthy children.
  • Cumulative OCP residues in sera and bone marrow are higher in children with malignant HDs versus non-malignant HDs.
  • Findings suggest a potential association between OCP exposure and the development or progression of pediatric hematological disorders.
Abstract

Keywords:
Aplastic anemiaCancerChildhoodDDTLeukemiaPesticideStockholm convention

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