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[Multiple squamous cell carcinomas arising in linear porokeratosis]
Dorothee A Busch1,2, Carola Berking3,4, Stefan Schliep3,4
1Hautklinik, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland. dorothee.busch@uk-erlangen.de.
Dermatologie (Heidelberg, Germany)
|August 19, 2025
Summary
This case report highlights a patient with linear porokeratosis who developed squamous cell carcinoma. Early biopsy and diligent monitoring are crucial for managing this rare keratinization disorder and its malignant transformation risk.
Area of Science:
- Dermatology
- Oncology
Background:
- Porokeratosis is a rare keratinization disorder with a known risk of malignant transformation.
- Linear porokeratosis presents with characteristic hyperkeratotic lesions that can evolve over time.
Purpose of the Study:
- To report a case of linear porokeratosis with subsequent development of cutaneous squamous cell carcinoma.
- To emphasize the importance of early diagnosis and monitoring in patients with porokeratosis.
Main Methods:
- Case presentation of a 58-year-old patient with linear porokeratosis.
- Biopsy confirmation of squamous cell carcinoma in multiple lesions.
- Surgical excision and secondary wound healing.
Main Results:
- Successful excision of squamous cell carcinoma lesions.
- Demonstration of malignant transformation in a case of linear porokeratosis.
- Highlighting the challenges in long-term management and efficacy of treatments.
Conclusions:
- Porokeratosis necessitates vigilant monitoring due to its potential for malignancy.
- Early biopsy of chronic, non-healing wounds is critical for timely diagnosis.
- Patient education and regular follow-up are essential for managing malignancy risk.
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