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The INSPIRE-T longitudinal observational study centered on intrinsic capacity: baseline data
Sophie Guyonnet1,2, Claudie Hooper1, Christelle Cantet1,2
1Department of Geriatrics, Institute Hospital-Universitaire (IHU) HealthAge, Gérontopôle, CHU Toulouse, Toulouse, France.
Summary
The INSPIRE-T study tracks aging trajectories using intrinsic capacity (IC) assessments. Early screening reveals prevalent vision, audition, and cognition declines, informing personalized healthy aging interventions.
Area of Science:
- Gerontology and Aging Research
- Translational Medicine
- Biomarker Discovery
Background:
- The INSPIRE-T study is a 10-year observational research initiative.
- It focuses on understanding aging trajectories via intrinsic capacity (IC) assessment.
Purpose of the Study:
- To investigate aging pathways across the lifespan.
- To identify individuals at risk for intrinsic capacity decline.
- To develop personalized interventions for healthy aging.
Main Methods:
- Utilized the World Health Organization's (WHO) integrated care for older people (ICOPE) program for IC assessment.
- Collected extensive biospecimens for biomarker analysis and drug-target identification.
- Stratified cohort by age (10-year groups) for detailed analysis.
Main Results:
- Baseline data from 1109 participants (aged 20-102 years) analyzed.
- Most common IC issues: vision (89.3%), audition (30.5%), cognition (24.7%).
- Observed sex-specific differences in psychological well-being, audition, vitality, and vision.
Conclusions:
- The study aims to identify individuals susceptible to intrinsic capacity decline.
- Personalized preventive strategies will be developed to promote healthy aging.
- Findings support proactive health management for aging populations.
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