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Related Experiment Videos

Descending optic nerve degeneration in primates.

H A Quigley, E B Davis, D R Anderson

    Investigative Ophthalmology & Visual Science
    |September 1, 1977
    PubMed
    Summary

    Optic nerve injury in monkeys caused simultaneous axon degeneration, not progressive disintegration. This suggests a rapid injury signal travels to the cell body, but its mechanism remains unknown.

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    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Cell Biology

    Background:

    • Optic nerve injury triggers axonal degeneration.
    • Understanding the timing and mechanism of this degeneration is crucial for developing treatments.

    Purpose of the Study:

    • To investigate the pattern and timing of descending optic nerve axon degeneration after injury.
    • To determine if degeneration progresses retrogradely from the injury site to the cell body.

    Main Methods:

    • Optic nerve transection at the orbital apex in squirrel monkeys.
    • Assessment of axonal degeneration using ultrastructural analysis.
    • Monitoring of slow axonal transport to evaluate physiological function.

    Main Results:

    • Simultaneous degeneration of the entire axon length observed, not a progressive disintegration.
    • Degeneration occurred between 3 and 6 weeks post-injury, irrespective of injury distance from the cell body.
    • Slow axonal transport indicated continued local physiological function during degeneration.

    Conclusions:

    • Axotomy appears to initiate a rapid, non-progressive degeneration signal to the entire axon.
    • The nature of this injury signal and its role in cell death require further investigation.

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