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(±)-Agrimonolide: Efficient synthesis and treatment of inflammatory bowel disease via JAK1/STAT3 pathway inhibition
Xiao Zhang1, Mingqian Ju1, Nanting Zou1
1Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming 650500, China; School of Chinese Materia Medica, School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.
Abstract:
Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal disorder. Here, we developed an efficient total synthesis of (±)-agrimonolide, a compound derived from the traditional medicine Agrimonia pilosa Ledeb., and evaluated its anti-inflammatory effects in a DSS-induced ulcerative colitis (UC) mouse model. Treatment with (±)-agrimonolide significantly ameliorated colonic inflammation, as evidenced by reducing mucosal damage, decreasing inflammatory cell infiltration, and suppressing the JAK1/STAT3 pathway activation in colonic tissues. These findings strongly suggest that (±)-agrimonolide may serve as a potential therapeutic agent for treating IBD.
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