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Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Advancing Human Brain Modulation – Optimized Protocols for Transcranial Ultrasound Stimulation Experiments

Author Spotlight: Advancing Human Brain Modulation – Optimized Protocols for Transcranial Ultrasound Stimulation Experiments

Published on: June 28, 2024

Pixel-responsive optimization beamforming method for ultrasound transcranial imaging.

Junyi Wang¹, Tianhua Zhou¹, Gaobo Zhang¹

¹College of Biomedical Engineering, Fudan University, Shanghai, 200433, China.

Medical Image Analysis

|August 19, 2025

Summary

A new Pixel-Responsive Optimization (PRO) beamforming method improves transcranial ultrasound imaging by correcting skull-induced wave distortions. This technique enhances image resolution and signal recovery for clearer brain imaging through bone.

Keywords:

Beamforming method Phase distortion Scattering medium Ultrasound transcranial imaging

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An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

Area of Science:

Medical Imaging
Acoustics
Biomedical Engineering

Background:

Skull bone significantly distorts acoustic waves, challenging transcranial ultrasound imaging.
Conventional delay-and-sum (DAS) algorithms struggle with skull-induced aberrations due to their pixel-independent processing.
Accurate ultrasound wave propagation through bone is crucial for effective brain imaging.

Purpose of the Study:

To develop an advanced beamforming method for overcoming acoustic distortions caused by bone in ultrasound imaging.
To improve image resolution and signal recovery in transcranial ultrasound applications.
To provide a generalizable solution for in vivo brain imaging through the skull.

Main Methods:

Proposed a Pixel-Responsive Optimization (PRO) beamforming method utilizing compound plane wave backscatter.
Constructed a pixel-response matrix and simulated a virtual acoustic lens to align distorted wavefields.
Tested the PRO method on bovine femur and human skull samples.

Main Results:

PRO demonstrated significant improvements in image resolution and recovery of submerged signals.
Achieved up to a 90% improvement in full-width at half-maximum (FWHM) compared to DAS.
Showcased artifact suppression and strong generalizability in complex bone-penetrating scenarios.

Conclusions:

The PRO beamforming method effectively corrects acoustic wave distortions in bone.
PRO offers a promising advancement for in vivo transcranial brain imaging.
This technique enhances the feasibility of ultrasound for neurological diagnostics through the skull.