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Annulate lamellae observed in human prostatic carcinoma
Acta Pathologica Japonica
|September 1, 1985
Summary
Annulate lamellae (AL) are rare structures found in human prostate cancer cells, not in benign or normal tissues. These structures appear to be temporary transitional forms between the nuclear membrane and the endoplasmic reticulum.
Area of Science:
- Cell Biology
- Oncology
- Prostate Cancer Research
Background:
- Annulate lamellae (AL) are complex membrane structures observed in various cell types.
- Their presence and significance in human prostatic tissues, particularly in cancer, remain underexplored.
Purpose of the Study:
- To investigate the occurrence and ultrastructural characteristics of annulate lamellae in human prostatic carcinoma.
- To compare the presence of AL in cancerous versus benign and normal prostatic tissues.
Main Methods:
- Electron microscopy was used to examine tissue samples.
- Human prostatic tissues from carcinoma, benign hyperplasia, and normal cases were analyzed.
Main Results:
- Annulate lamellae were detected in only 3 out of 40 prostate carcinoma cases.
- AL were absent in all examined cases of benign prostatic hyperplasia and normal prostatic tissues.
- AL exhibited continuity with the nuclear membrane and rough endoplasmic reticulum, featuring stacked membranes and annuli.
Conclusions:
- Annulate lamellae are rare in human prostate cancer, suggesting they may be specific to actively dividing cancer cells.
- AL likely represent transient structures involved in the transformation between the nuclear membrane and the rough endoplasmic reticulum.