Related Experiment Video
Updated: Sep 10, 2025
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
Association of possible sarcopenia and its components with all-cause mortality in a middle-aged and older population:
Zhiping Duan1, Guihua Jiang1, Yingxia Zhu1
1Department of Geriatrics, The Third People's Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, 292 Beijing Road, Kunming, 650011, Yunnan Province, China.
Insights
Possible sarcopenia, characterized by low handgrip strength or slow chair stand times, significantly increases all-cause mortality risk in Chinese adults aged 45+. Early identification of these aging indicators is crucial for public health.
Area of Science:
- Gerontology and Geriatric Medicine
- Public Health and Epidemiology
- Musculoskeletal Health
Background:
- Sarcopenia, an age-related decline in muscle mass and function, is linked to adverse health outcomes.
- The association between possible sarcopenia and its components with all-cause mortality requires further investigation, particularly in diverse populations.
- Early identification of sarcopenia risk factors is essential for timely intervention in community-dwelling older adults.
Purpose of the Study:
- To analyze the association between possible sarcopenia and its components (handgrip strength, 5-time chair stand test) and all-cause mortality.
- To investigate these associations in a large cohort of Chinese middle-aged and older adults.
- To provide evidence for the clinical significance of identifying possible sarcopenia in primary care settings.
Main Methods:
- A cohort study utilizing data from 11,233 participants aged ≥45 years from the 2011-2020 China Health and Retirement Longitudinal Study.
- Possible sarcopenia was defined using the Asian Working Group for Sarcopenia 2019 criteria: low handgrip strength or 5-time chair stand test ≥12 seconds.
- Cox proportional risk models were employed to assess the association between possible sarcopenia, its components, and all-cause mortality.
Main Results:
- Possible sarcopenia was significantly associated with an increased risk of all-cause mortality (HR 1.77, 95% CI 1.55-2.02, p<0.001).
- Both low handgrip strength (HR 1.51, 95% CI 1.18-1.93, p=0.001) and a slow 5-time chair stand test (HR 1.61, 95% CI 1.39-1.87, p<0.001) independently increased mortality risk.
- The combination of both low handgrip strength and slow chair stand test further elevated all-cause mortality risk (HR 2.54, 95% CI 2.11-3.06, p<0.001).
Conclusions:
- Possible sarcopenia and its individual components are significant risk factors for all-cause mortality in Chinese middle-aged and older adults.
- These findings underscore the importance of screening for possible sarcopenia and its components in primary care for risk stratification and intervention.
- Identifying individuals with low muscle strength and poor physical performance can aid in proactive health management and potentially reduce mortality.
Abstract:
The association of possible sarcopenia and its components with all-cause mortality needs further study. This study analyzed the association of possible sarcopenia, handgrip strength and 5-time chair stand test with all-cause mortality in a Chinese middle-aged and older community population. This cohort study included a total of 11,233 participants aged ≥ 45 years from the 2011-2020 China Health and Retirement Longitudinal Study. Diagnostic criteria for possible sarcopenia are based on Asian Working Group for Sarcopenia 2019: low handgrip strength or 5-time chair stand test ≥ 12 s. The association of possible sarcopenia and its components with all-cause mortality was assessed by Cox proportional risk models. The results showed that possible sarcopenia was associated with an increased risk of all-cause mortality, hazard ratio (HR) and 95% confidence interval (CI) 1.77 (1.55-2.02), p < 0.001. Both low handgrip strength and 5-time chair stand test ≥ 12 s significantly increased the risk of all-cause mortality, with HRs and 95%CIs of 1.51 (1.18-1.93), P = 0.001 and 1.61 (1.39-1.87), P < 0.001, respectively; when both were present, the risk of all-cause mortality was further elevated, HR and 95%CI 2.54 (2.11-3.06), P < 0.001. Possible sarcopenia and its components are all associated with a higher mortality and it is important to identify these risk factors in primary care.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:19The Effect of Aging on Tissues
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:28Menopause
01:26Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
02:20Longitudinal Research